Clinical Trial: New Magnesium Sulphate Protocol for Pre-eclampsia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: The Best Magnesium Sulphate Protocol for Severe Pre-eclampsia : A Randomized Controlled Trial
Brief Summary: there is a standard magnesium sulphate protocol and newer protocols for pre-eclampsia, we need to make a trial to find the best protocol
Detailed Summary:
The aim of our study is to assess the comparative effects of three regimens for the administration of magnesium sulfate when used for the care of women with severe pre-eclampsia.
The study will include 240 pregnant women presenting to the casualty unit with criteria of severe preeclampsia in the form of one of the criteria:-
- Systolic blood pressure ≥ 160.
- Diastolic blood pressure ≥ 110.
- Proteinuria > +2 by dip stick.
- Presence of alarming symptoms (headache, visual disturbance, epigastric pain, vaginal bleeding).
- Fetal growth restriction (IUGR).
After obtaining an informed consent the patients will be subjected to the following:
- Careful history taking including age, parity, gestational age.
- Complete physical examination and assessment of the blood pressure.
- Urine analysis by dipstick.
- All women will take initial MgSO4 (6 grams of MgSO4 on 250 ml ringer solutions over 20 minutes by IV drip) .
Using Random Number Table, the sample size will be divided into three categories:-
- Category A : 80 patients given full dose of maintenance MgSO4 (4 grams of MgSO4 on 250 ml ringer solution over 4 hours every 4 hours by IV drip for 24 hours) in the postpartum period.
- Category B : 80 patients given abbreviated doses of MgSO4 (4 grams of MgSO4 on
Sponsor: Cairo University
Current Primary Outcome: duration of MgSo4 treatment [ Time Frame: 1 year ]
treatment duration
Original Primary Outcome: convulsion rate [ Time Frame: 1 year ]
convulsion
Current Secondary Outcome: ICU admission [ Time Frame: 1 year ]
ICU admission
Original Secondary Outcome: Same as current
Information By: Cairo University
Dates:
Date Received: May 1, 2013
Date Started: May 2013
Date Completion:
Last Updated: August 21, 2014
Last Verified: August 2014