Clinical Trial: Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia

Study Status: Terminated
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia: A Double-Blinded, Randomized, Placebo-Controlled Study

Brief Summary: The investigators previously demonstrated that epidural ropivacaine reduces uterine artery vascular resistance in a dose dependent manner in pre-eclampsia. The investigators also noted a marked right-left difference in vascular resistance between paired uterine arteries, which was almost completely abolished following epidural ropivacaine. However, this novel observation was not a stated outcome variable before the study began. This study assesses right-left difference in vascular resistance between paired uterine arteries as a primary end-point, assesses the dose-response effect of epidural lidocaine and compares the effect observed in pre-eclampsia with that in two control populations (term normal pregnancy and non-pregnant controls).

Detailed Summary:
Sponsor: Hadassah Medical Organization

Current Primary Outcome: Uterine artery pulsatility index (by Doppler ultrasound). Specifically the right-left uterine artery difference. [ Time Frame: 15min after each dose - on a dose--response curve ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Uterine artery pulsatility index (worse vessel) [ Time Frame: 15 min after dose ]

Original Secondary Outcome: Same as current

Information By: Hadassah Medical Organization

Dates:
Date Received: February 19, 2009
Date Started: March 2009
Date Completion: October 2009
Last Updated: February 19, 2009
Last Verified: February 2009