Clinical Trial: CA-125 and Severity of Pre-Eclampsia

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: CA-125 and Severity of Pre-Eclampsia

Brief Summary: The Aim of this study is to determine the relationship between serum concentrations of cancer antigen-125 (CA-125) and pre-eclampsia severity.

Detailed Summary:

Although the source of CA-125 during pregnancy is the fetal chorion, amniotic fluid, and maternal decidua, the perinatal dynamics of maternal serum CA-125 requires clarification. Clinical studies of CA-125 levels and its function in hypertensive pregnant patients are limited and offered contradictory results (Cebesoy et al., 2009).

And so we investigate CA-125 in normal pregnancy and in pre-eclampsia, comparing mild and sever pre-eclampsia to determine relationship of CA-125 and severity of the disease.

Patients will be divided in three groups:

  • Control: 40 normal healthy pregnant women attending the ER in labor.

  • Mild pre-eclampsia: 40 patients fulfilling the following criteria.

    • Blood pressure: systolic blood pressure >140 and <160 , Diastolic blood pressure >90 and <110
    • Proteinuria: 300 mg (+) assessed by urine urignost 3A® (urine strips from DIALAB).
    • No symptoms of severity as headache.
    • Normal investigations for different organ function (as liver and kidney function).

  • Severe pre-eclampsia :40 patients fulfilling anyone or more of the following criteria (The American College of Obstetricians and Gynecologists, 2010)(ACOG):

    • Systolic blood pressure > 160 mmHg
    • Diastolic blood pressure > 110 mmHg (on two occasions at least 6 hours apart while the patien
      Sponsor: Ain Shams Maternity Hospital

      Current Primary Outcome: increase serum CA-125 in pre-eclamptic patients [ Time Frame: 1 year ]

      measuring serum CA-125


      Original Primary Outcome: Same as current

      Current Secondary Outcome:

      Original Secondary Outcome:

      Information By: Ain Shams Maternity Hospital

      Dates:
      Date Received: March 3, 2016
      Date Started: March 2016
      Date Completion: September 2016
      Last Updated: March 17, 2016
      Last Verified: March 2016