Clinical Trial: LXRs, Cholesterol Metabolism and Uterine Dystocia

Study Status: Terminated
Recruit Status: Terminated
Study Type: Observational

Official Title: The Role of Two Nuclear Receptors for Oxysterols as a Molecular Cause of Uterine Dystocia: LXR Alpha and LXR Beta

Brief Summary: Despite the fact that a link between cholesterol and the myometrium has been clearly established, no study investigating aspects of cholesterol metabolism and uterine dystocia currently exists. This study is a pilot study whose aim is to test the hypothesis that an association between uterine dystocia and single-nucleotide polymorphisms (SNPs) in the genes coding for the LXRs.

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire de Nīmes

Current Primary Outcome: The multi-loci genotype of the target DNA sequence. [ Time Frame: Day 1 ]

The polymorphisms of interest are the following SNPs: rs3758673, rs3758674, rs12221497, rs11039155, rs2279238, rs7120118, rs35463555, rs1052533, rs2248949, rs41432149, rs1405655, rs4802703.


Original Primary Outcome: The genotype comprised of the homozygous of heterozygous status of the target DNA sequence for each of the polymorphisms of interest.

The polymorphisms of interest are the following SNPs: rs3758673, rs3758674, rs12221497, rs11039155, rs2279238, rs7120118, rs35463555, rs1052533, rs2248949, rs41432149, rs1405655, rs4802703. There is no time frame for such variables. Genotypes don't change with time.


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Centre Hospitalier Universitaire de Nīmes

Dates:
Date Received: April 14, 2010
Date Started: April 2010
Date Completion:
Last Updated: November 19, 2015
Last Verified: November 2015