Clinical Trial: Treatment of Depression Following Multiple Brain Tests

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Medication Treatment Following Neuropsychologic, Dichotic and f-MRI Tests in Depressed Outpatients With Repeat f-MRI Following Treatment

Brief Summary: The main purpose of this study is to correlate brain testing with treatment outcome.

Detailed Summary: 40 medication-free Depressed Patients will receive a battery of neuropsychologic tests, standard dichotic listening tests, EEG, ERP and an f-MRI while performing a neuropsychologic test, the Simon. Once testing is completed, patients will be treated in an open treatment trial of SSRI. Non-responders will then receive Bupropion followed by Tricyclic Antidepressant if still depressed. While our main purpose is to correlate imaging testing with other measures of brain functioning, we also intend to see whether f-MRI findings demonstrate specific brain areas which differ between responders and non-responders. At the end of SSRI treatment, patients will have a second f-MRI scan to investigate any changes treatment and/or response may have caused.
Sponsor: New York State Psychiatric Institute

Current Primary Outcome: Hamilton Depression Scale (HAM-D) [ Time Frame: 7 mos. ]

Original Primary Outcome:

  • Hamilton Depression Scale (HAM-D)
  • EEG recordings
  • ERP recordings
  • f-MRI
  • STROOP test
  • Simon Test
  • Word Production
  • Wisconsin Card Sort
  • Block Design
  • Letter Trials
  • Chimeric Faces
  • NAR-T
  • Digit Symbol Coding
  • Syllables Test
  • Tones Test
  • Rhymed Words Test


Current Secondary Outcome:

  • Beck Depression Inventory (BDI) [ Time Frame: 7 mos. ]
  • Clinical Global Impression (CGI) [ Time Frame: 7 mos. ]
  • Patient Global Impression (PGI) [ Time Frame: 7 mos. ]
  • Inventory of Depressive Symptoms (IDS) [ Time Frame: 7 mos. ]
  • Edinburgh Handedness Inventory [ Time Frame: 7 mos. ]
  • Chapman Pleasure Scale [ Time Frame: 7 mos. ]
  • Spielberger State/Trait Anxiety Inventory [ Time Frame: 7 mos. ]


Original Secondary Outcome:

  • Beck Depression Inventory (BDI)
  • Clinical Global Impression (CGI)
  • Patient Global Impression (PGI)
  • Inventory of Depressive Symptoms (IDS)
  • Edinburgh Handedness Inventory
  • Chapman Pleasure Scale
  • Spielberger State/Trait Anxiety Inventory


Information By: New York State Psychiatric Institute

Dates:
Date Received: February 23, 2006
Date Started: December 2004
Date Completion:
Last Updated: April 26, 2012
Last Verified: April 2012