Clinical Trial: Dyspnea in COPD: Relationship With Exacerbations Frequency
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Breathlessness Perception in COPD: Relationship With Exacerbation Frequency
Brief Summary:
The perception of breathlessness varies significantly among COPD patients with similar severity of airflow limitation; those with poorer perception report less exacerbations as compared to those with frequent exacerbations.
Cross-sectional comparison of breathlessness perception in COPD patients with frequent exacerbations or without frequent exacerbations.
To assess "Breathlessness Perception" the investigators will increase the ventilatory demand of the patients by CO2-rebreathing method.
Detailed Summary:
The perception of breathlessness varies between individuals. This is a well-established concept in asthma, but mostly unexplored in COPD; the relationship between airflow limitation (FEV1, % ref.) and breathlessness (mMRC) is weak.
The perception of breathlessness varies significantly among COPD patients with similar severity of airflow limitation; those with poorer perception report less exacerbations as compared to those with frequent exacerbations.
It is a cross-sectional comparison of breathlessness perception in COPD patients with frequent exacerbations (≥2 or ≥1 with hospitalization in the previous year) or without frequent exacerbations (0 or 1 without hospitalization in the previous year).
To assess "Breathlessness Perception" the investigators will increase the ventilatory demand of the patients by CO2-rebreathing method. CO2 rebreathing test will be conducted to evaluate the acute ventilatory response to CO2 inhalation used to estimate central chemoreceptor responsiveness in patients with the obstructive pulmonary disease.
Simple descriptive statistics (unpaired T-test) and correlation analysis (bivariate and multivariate) will be used to analyze results.
Sponsor: Hospital Clinic of Barcelona
Current Primary Outcome: The negative airway pressure generated during the first 100 ms of an occluded inspiration, which is an estimation of the neuromuscular drive to breathe. (P01 ) [ Time Frame: Baseline ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Borg scale [ Time Frame: Baseline ]10-point subjective scoring system, in which a patient rates his/her effort of exertion.
- Fractional exhaled nitric oxide (FeNO) [ Time Frame: Baseline ]
- Inspiratory capacity (IC) [ Time Frame: Baseline ]The sum of inspiratory reserve volume and tidal volume.
- Ventilation at rest [ Time Frame: Baseline ]
- CO exhaled test [ Time Frame: Baseline ]Testing for Carbon Monoxide in exhaled breath in current smokers.
Original Secondary Outcome: Same as current
Information By: Hospital Clinic of Barcelona
Dates:
Date Received: April 4, 2014
Date Started: April 2014
Date Completion:
Last Updated: August 19, 2015
Last Verified: April 2014
