Clinical Trial: Comparison of Pantoprazole and Ranitidine in Dyspepsia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Intravenous Pantoprazole vs Ranitidine in Dyspepsia in Emergency Department: A Randomized Controlled Trial.

Brief Summary:

The H0 hypothesis of the study is there is no difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department.

The H1 hypothesis is there is difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department.


Detailed Summary: Dyspepsia is one of the common complaints in emergency department. Proton pomp inhibitors, H2 receptor blockers and anti-acids are common drugs for treating dyspepsia in emergency department. However there is no study in the emergency department comparing the effectiveness of these drugs. So the investigators planned this study which drug is effective in these patients in order to provide a cost-effective treatment in dyspeptic patients.
Sponsor: Akdeniz University

Current Primary Outcome: Visual Analogue Scale Score [ Time Frame: 30th and 60th minutes ]

The investigators are measuring the change of pain from the baseline to the 30th and 60th minutes by visual anologue scale (VAS). Visual Analogue Scale measurement is between 0 (no pain) and 100 (worst pain). A decrease of 13 or 16 mm in VAS score is accepted as a minimum clinically significant change in pain.


Original Primary Outcome: Visual Analogue Scale Score [ Time Frame: 30th and 60th minutes ]

The investigators are measuring the change of pain from the baseline to the 30th and 60th minutes by visual anologue scale.


Current Secondary Outcome: Need for Additional Drug [ Time Frame: 60 th minute ]

The investigators are measuring the need for additional drug at the end of 60 minutes.


Original Secondary Outcome: Same as current

Information By: Akdeniz University

Dates:
Date Received: November 24, 2012
Date Started: October 2012
Date Completion:
Last Updated: June 27, 2015
Last Verified: June 2015