Clinical Trial: Prediction and Intervention in Developmental Dyslexia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Neuronal Markers of Grapheme-phoneme Training Response for Prediction of Successful Reading Acquisition in Children at Familial Risk for Developmental Dyslexia

Brief Summary: The long-term goal of this study is to improve prediction of poor reading outcome at preschool age by using a combination of behavioural and neuroimaging measures and to evaluate a specific computerized training program to support children with problems during reading acquisition.

Detailed Summary:
Sponsor: University of Zurich

Current Primary Outcome: Changes in reading and spelling performance [ Time Frame: Participants will be tested at three times for the duration of the cross-sectional intervention, an expected average of 8 months ]

Performance in normed reading and/or spelling (standardized tests) as a result of reading acquisition and training


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Developmental and training induced changes in functional brain activation and brain structure [ Time Frame: Participants will be tested after an expected average of 8, 12 and 16 months ]
    Changes in activation/structure of core language network regions assessed by EEG and MRI during development, learning and training
  • Accuracy of prediction on reading performance outcome [ Time Frame: Participants will be tested at T1 and on average 8 months later ]

    Accuracy of prediction on reading performance (standardized tests) using behavioural and/or neuroimaging measures.

    Neuroimaging measures: EEG and MRI (functional activation, structural measures from white and/or grey matter, temporal information from event-related potential and/or frequency analyses)



Original Secondary Outcome: Same as current

Information By: University of Zurich

Dates:
Date Received: August 8, 2014
Date Started: July 2013
Date Completion: July 2018
Last Updated: August 13, 2014
Last Verified: August 2014