Clinical Trial: Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Dyslexia)
Brief Summary: This study aims to determine whether levodopa, in combination with a high frequency training of (grammatical) rules, is effective in boosting learning success in healthy subjects and whether this kind of training in combination with levodopa improves reading and spelling abilities of patients with dyslexia.
Detailed Summary: Prior work by our group shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind trial, we probe whether daily administration of levodopa, coupled with a training of grammatical rules, improves the training success in healthy adults as compared to placebo administration. In the second step of this study, patients with dyslexia will be trained with the identical protocol. We postulate that the combination of intensive training in language rules and levodopa improves the reading, writing, and spelling abilities of patients with dyslexia.
Sponsor: University Hospital Muenster
Current Primary Outcome:
- Boost in training success (percent correct) through levodopa as compared to placebo
- Boost in training success (reaction times) through levodopa as compared to placebo
- Increased performance on reading, spelling and writing tests in dyslexic patients treated with levodopa as compared to placebo
Original Primary Outcome: Same as current
Current Secondary Outcome: Stability of improvements one month post training
Original Secondary Outcome: Same as current
Information By: University Hospital Muenster
Dates:
Date Received: May 19, 2005
Date Started: January 2005
Date Completion: October 2015
Last Updated: December 4, 2014
Last Verified: September 2006
