Clinical Trial: Maturation of Auditory Processing in Children With Dyslexia Compared to Average-reading Children

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Asymmetry, Auditory Processing and Reading Skills in Phonological Dyslexic Children Compared to Average-reading Children

Brief Summary: The hypothesis of central auditory processing disorders has been advanced to explain the anomalies of the grapheme/phoneme combination in some dyslexia. These phonological disorders may be linked to abnormalities of the efferent (medial olivocochlear) system modulation and of cortical asymmetry. Indeed, the efferent system has an asymmetry in relation to handedness. Thus, in right-handed subject, it is predominant on the right side. In contrast, in the subject-handed dyslexic, the efferent system tends to be right-lateralized or non-lateralized. However, after an audio-visual training, normal lateralization can appear. This maturation of the efferent system lateralization during reading acquisition seems to have a particular profile in dyslexics with phonological disorder, especially if it is persistent. This finding allows to consider new prognostic evaluation and speech therapy rehabilitation in the dyslexic child.

Detailed Summary:
Sponsor: Hospices Civils de Lyon

Current Primary Outcome: Change of The Asymmetry Index of the efferent system at 2 years interval [ Time Frame: Day 1 and then at least 2 years (± 4 weeks) ]

The change of the Asymmetry Index of the efferent system The Asymmetry Index is the difference between the equivalent attenuation measured on the right ear and the left ear. Evoked otoacoustic emissions were recorded monaurally at five stimulus intensities ranging from 57 to 69 dB SPL in 3 dB steps, in random presentation order, with and without contralateral acoustic stimulation consisting of 30 dBSPL continuous broadband noise (speech-like noise) produced by an audiometer


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Change in the level of reading skill [ Time Frame: Day 1 and then at least 2 years (± 4 weeks) ]
    Behavioral measure
  • Change in the percentage of correct answers obtained during a speech perception test in silence and noise. [ Time Frame: Day 1 and then at least 2 years (± 4 weeks) ]
    Oral repetition of VCV
  • Change in percentage of correctly repeated stimuli which have been heard in both ears (binaural integration with divided attention) or in one indicated ear (binaural separation with selective attention) [ Time Frame: Day 1 and then at least 2 years (± 4 weeks) ]
    Presentation of different speech material to both ears simultaneously


Original Secondary Outcome: Same as current

Information By: Hospices Civils de Lyon

Dates:
Date Received: December 9, 2014
Date Started: March 2014
Date Completion: February 2019
Last Updated: August 26, 2016
Last Verified: August 2016