Clinical Trial: Aripiprazole for Neuroleptic-Induced Tardive Dyskinesia
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Aripiprazole for Pre-Existing Neuroleptic-Induced Tardive Dyskinesia: a Prospective 26-Week Observational Study
Brief Summary: The aim of the present study was to investigate the efficacy of aripiprazole in management of pre-existing neuroleptic-induced tardive dyskinesia
Detailed Summary:
Objective:A few case reports on the use of aripiprazole in neuroleptic-induced tardive dyskinesia have demonstrated positive effects. However its effectiveness in treatment of TD was still inconclusive. The aim of the present study was to investigate the efficacy of aripiprazole in management of pre-existing neuroleptic-induced tardive dyskinesia.
Method: Subjects with pre-existing neuroleptic-induced tardive dyskinesia were chosen from Taoyuan psychiatric center. Patients recruited would be treated with aripiprazole for cross-titration with previous antipsychotics in 8 weeks. We use AIMS, SAS, & BAS to assess the severity of TF and EPS. We record subjects' age, sex, and other factors which have influence at the treatment response. Subjects are assessed every two weeks in the first month and then monthly until six months.
Sponsor: Taoyuan Psychiatric Center, Ministry of Health and Welfare, Executive Yuan, R.O.C. Taiwan
Current Primary Outcome: Total scores of AIMS [ Time Frame: The change from baseline to study endpoint ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Total scores of PANSS [ Time Frame: The change from baseline to study endpoint ]
- Total scores of SAS [ Time Frame: The change from baseline to study endpoint ]
Original Secondary Outcome: Same as current
Information By: Taoyuan Psychiatric Center, Ministry of Health and Welfare, Executive Yuan, R.O.C. Taiwan
Dates:
Date Received: February 4, 2009
Date Started: June 2008
Date Completion: February 2010
Last Updated: February 4, 2009
Last Verified: February 2009
