Clinical Trial: Effects of Environmental Factors on Opiate Drug Choice in Opioid Dependent Individuals.

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Biobehavioral Study of Opioid Drug Seeking Behavior: Study 3

Brief Summary: The purpose is to study how certain factors, including money, the amount of drug available and the amount of work effort, affect opiate drug choice.

Detailed Summary:

A drug dependent person chooses to take drug more often (and suffer its long-term bad consequences) than choosing to engage in healthy activities (which have better long-term consequences). The present research will be conducted in a controlled laboratory setting with heroin abusers who are not seeking treatment to understand what factors guide their choices.

This research focuses on environmental (i.e. non-medication) factors that affect choosing a drug versus money. Findings from this research are likely to be important in developing a theoretical and practical basis for behavioral interventions as part of drug abuse treatment. HYD is a drug that is currently used as a cough suppressant and to relieve pain.

Participants in this observational study will take part in multiple trials in which they have the opportunity to choose HYD or money. On the first two experimental days, prior to choice sessions, participants will receive a sample of the drug doses that can be chosen. During test sessions, participants will have 12 opportunities to choose either drug or money. Participants will use a computer to earn choices. Respiration rate, oxygen saturation, heart rate, and blood pressure will be monitored throughout choice trials. Self-report questionnaires will be completed at different times during the study.

Participants will be maintained on buprenorphine throughout the study, with a minimum 2-week lead before the experiment, and a fixed 3-week detoxification after study completion.

Sponsor: Wayne State University

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Information By: Wayne State University

Dates:
Date Received: January 31, 2008
Date Started: July 2007
Date Completion:
Last Updated: June 1, 2012
Last Verified: June 2012