Clinical Trial: Immunological and Viral Parameters in Patients Receiving Anti-epileptic Drugs

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Immunological and Viral Parameters in Patients Receiving Anti-epileptic Drugs

Brief Summary: A recent study has shown that certain drug allergies were actually related to an immune system against certain viruses. The aim of the study is to evaluate, in patients taking antiepileptic drugs, if this treatment induces proliferation of these viruses and secondarily an immune response that would promote the development of a rash. In particular, will be studied whether these drugs can induce virus reactivation "dormant" in the immune system. This study will not affect the usual follow-up proposed by investigators, with the exception of some additional blood samples.

Detailed Summary:
Sponsor: University Hospital, Rouen

Current Primary Outcome:

  • Number of patients with viral reactivation of Epstein-Barr Virus [ Time Frame: 3 Months ]
    Number of patients with viral reactivation of Epstein-Barr Virus is evaluated in patients initiating an anti-epileptic treatment
  • Number of patients with viral reactivation of Human Herpes Virus 6 [ Time Frame: 3 Months ]
    Number of patients with viral reactivation of Human Herpes Virus 6 is evaluated in patients initiating an anti-epileptic treatment
  • Number of patients with viral reactivation of Human Herpes Virus 7 [ Time Frame: 3 Months ]
    Number of patients with viral reactivation of Human Herpes Virus 7 is evaluated in patients initiating an anti-epileptic treatment


Original Primary Outcome: Same as current

Current Secondary Outcome: Change from baseline in lymphocyte population count [ Time Frame: 3 Months ]

Lymphocyte population count will be compared between baseline and 3 months after the treatment initiation


Original Secondary Outcome: Same as current

Information By: University Hospital, Rouen

Dates:
Date Received: September 18, 2015
Date Started: May 2013
Date Completion:
Last Updated: January 22, 2016
Last Verified: January 2016