Clinical Trial: Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Neuronal Excitability of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN1) Channel Mutations in Dravet Syndrome
Brief Summary: This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.
Detailed Summary:
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Current Primary Outcome:
- hyperpolarizing electrotonus [ Time Frame: baseline ]
- hyperpolarizing threshold current [ Time Frame: baseline ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Fondation Ophtalmologique Adolphe de Rothschild
Dates:
Date Received: August 23, 2016
Date Started: October 2015
Date Completion: December 2017
Last Updated: February 3, 2017
Last Verified: February 2017
