Clinical Trial: Treatment of Orthostatic Hypotension

Study Status: Enrolling by invitation
Recruit Status: Enrolling by invitation
Study Type: Interventional

Official Title: Treatment of Hypotensive Patients Having a Unique Pattern of Autonomic Symptoms

Brief Summary: The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system. The pharmacological trials in this study will perhaps lead to more effective treatment. This study consists of single dose trials, dose selection trials, 5-day trials and chronic (approximately 2 months) trials.

Detailed Summary: We see many patients at the Autonomic Dysfunction Center who can be given a fairly definitive diagnosis, e.g., Orthostatic Intolerance, Pure Autonomic Failure, Multiple System Atrophy, and Baroreflex Failure. However, some patients present with a unique constellation of symptoms of autonomic dysfunction so that they do not fit into a diagnostic category. We hypothesize that a genetic cause exists in some of these patients. We further propose that our comprehensive evaluation of these patients will provide us with information on the pathophysiology of their condition and assist us in optimizing their treatment.
Sponsor: Vanderbilt University

Current Primary Outcome: Change in blood pressure with standing [ Time Frame: following 5 days of medication ]

Original Primary Outcome: Same as current

Current Secondary Outcome: length of time subject is able to stand [ Time Frame: following 5 days of medication ]

Original Secondary Outcome: Same as current

Information By: Vanderbilt University Medical Center

Dates:
Date Received: December 22, 2007
Date Started: January 2004
Date Completion: December 2017
Last Updated: April 3, 2017
Last Verified: April 2017