Clinical Trial: The Pathophysiology of Orthostatic Hypotension
Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional
Official Title: The Pathophysiology of Orthostatic Hypotension
Brief Summary: The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system. These patients frequently have had symptoms throughout their life, and their disorder might have a genetic basis. The biochemical, physiological and pharmacological procedures in this study should help us define the problem and perhaps lead to more effective treatment.
Detailed Summary:
Sponsor: Vanderbilt University
Current Primary Outcome: hemodynamic changes with standing [ Time Frame: following test ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- blood and urine hormones [ Time Frame: after test ]
- blood volume [ Time Frame: during supine and/or upright postures ]
- sympathetic nerve activity [ Time Frame: during stimulation of sympathetic nervous system ]
- quantitative sweat testing [ Time Frame: 2 hours ]
- Eye function [ Time Frame: once ]
- Sleep efficiency [ Time Frame: once ]
- Metabolic rate [ Time Frame: once ]
- Pain response [ Time Frame: once ]
- Responses on questionnaires and computer tasks designed to assess brain function [ Time Frame: once ]
Original Secondary Outcome:
- blood and urine hormones [ Time Frame: after test ]
- blood volume [ Time Frame: during supine and/or upright postures ]
- sympathetic nerve activity [ Time Frame: during stimulation of sympathetic nervous system ]
- quantitative sweat testing [ Time Frame: 2 hours ]
Information By: Vanderbilt University Medical Center
Dates:
Date Received: September 5, 2008
Date Started: December 1996
Date Completion: December 2017
Last Updated: April 19, 2017
Last Verified: April 2017
