Clinical Trial: Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?

Study Status: Completed
Recruit Status: Completed
Study Type: Observational [Patient Registry]

Official Title: Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?An ED Study

Brief Summary: Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of liver function tests for patients with SOD in the ED, and a cost analysis of liver function tests.

Detailed Summary: Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. The diagnosis of acute liver dysfunction (ALD) can usually be made by initial symptoms, physical examination, and biochemical tests, including liver function tests (LFTs) with high sensitivity and specificity. LFTs include albumin, bilirubin, coagulation factors (Activated Partial Thromboplastin Time (aPTT) and International Normalized Ratio (INR)), and liver enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), and y-glutamyl transpeptidase (GGT), which are marker of hepatic damage. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of LFTs for patients with SOD in the ED, and a cost analysis of LFTs.
Sponsor: Adiyaman University Research Hospital

Current Primary Outcome: LFTs serum levels by biochemical method ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, albumin, INR, aPTT, and Platelet count (PC) [ Time Frame: 5 months ]

The serum levels of LFTs will obtained by the laboratory analysis of blood samples of each participant.


Original Primary Outcome: LFTs serum levels by biochemical method group the levels of ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, albumin, INR, aPTT, and Platelet count (PC) [ Time Frame: 5 months ]

The difference between patient and control group the serum levels of ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, albumin, INR, aPTT, and PC which will obtained by the laboratory analysis of blood samples of each participant.


Current Secondary Outcome: The cost calculation for the LFTs [ Time Frame: 5 months ]

The cost for the LFTs will be calculated with financial data in invoices which will obtained from the hospital invoicing service.


Original Secondary Outcome: Same as current

Information By: Adiyaman University Research Hospital

Dates:
Date Received: March 27, 2016
Date Started: September 2012
Date Completion:
Last Updated: April 9, 2016
Last Verified: April 2016