Clinical Trial: Gene Expression in the Overactive Bladder in Children

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Gene Expression in the Bladder in Children With an Overactive Bladder and Daytime Urinary Incontinence

Brief Summary:

The aim of this study (the hypothesis) is to identify differences in the gene expression profile in the bladder muscle and hereby gain greater knowledge about the muscular mechanisms that cause overactive bladder and daytime urinary incontinence in children older than 5 years. A secondary aim is to examine how this gene expression profile differs from children with a neurogenic overactive bladder and how the gene expression profile changes from childhood till adulthood. Such new knowledge will result in a more precisely targeted and hence effective treatment of overactive bladder.

The results will be obtained by retrieving bladder biopsies from children and adults suffering from an overactive bladder or a neurogenic bladder. These biopsies will undergo molecular analysis and the investigators will compare them with biopises from bladder healthy adults and children.


Detailed Summary:
Sponsor: University of Aarhus

Current Primary Outcome: Up- and down regulation of genes expressed in the bladder [ Time Frame: collection of bladder material and analysis will take approximately 2 years ]

We will evaluate the gene expression (which genes are up- and/or down regulated) in the bladder in healthy children compared to children suffering from an overactive bladder. This gene expression will then be compared to the gene expression in bladder tissue from adults, to evaluate what happens in the bladder from childhood to adulthood.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Aarhus

Dates:
Date Received: March 6, 2014
Date Started: November 2013
Date Completion: November 2016
Last Updated: December 17, 2015
Last Verified: December 2015