Clinical Trial: Exploration of the Social Cognition in Adolescents With a Dissociative Disorder or Autism Spectrum

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: EXPLORATION OF THE SOCIAL COGNITION IN ADOLESCENTS WITH A Dissociative Disorder OR AUTISM SPECTRUM

Brief Summary:

The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.

Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attributi

Detailed Summary:

The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.

Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attributi
Sponsor: Centre Hospitalier Universitaire de Nice

Current Primary Outcome: Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition [ Time Frame: First day ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Compare the cognitive profiles within the clinical group of schizophrenic [ Time Frame: First day ]

  Compare the cognitive profiles within the clinical group of schizophrenic patients, depending on the type of schizophrenia presented (as positive, negative or disorganized).

  For the study of attribution of intentions to others: This is to test the understanding of metaphors patients. Three types of statements are presented: forward literals, metaphorical statements and statements incongruous; patients should judge the plausibility semantics of these sentences. We study the behavioral and electrophysiological data.

• Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients. [ Time Frame: First day ]

  Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients.

  Self-assessment in the form of a questionnaire with several social situations of everyday life. The subject must plan and assign intentionality to a character. We get scores dimensions studied.

Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Universitaire de Nice

Dates:
Date Received: February 22, 2013
Date Started: January 2013
Date Completion:
Last Updated: May 27, 2013
Last Verified: May 2013