Clinical Trial: Susceptibility to Chronic Post-Traumatic Extremity Pain
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Susceptibility to Chronic Post-Traumatic Extremity Pain
Brief Summary: The association between the COMT haplotypes and the presence or absence of CPSP or CRPS will be assessed stratifying the patients based on the individual categories of trauma or elective surgery.
Detailed Summary: This will be a prospective association study in which we will recruit patients who have experienced single extremity trauma, or who have scheduled elective surgery on a single extremity. HRQoL will be determined at recruitment. We will identify their haplotypes and genotypes for 4 linked SNPs in the coding region of COMT as described by Diatchenko [2]. Patients will receive follow-up at 3 and 6 months following trauma or surgery. Individuals who report either neuropathic pain or a reduced HRQoL score will be more closely examined, in order to identify CPSP or CRPS. Statistical analyses will be performed to determine whether haplotypes are associated with the development of either condition, and to determine the strength of this association.
Sponsor: William Beaumont Hospitals
Current Primary Outcome: Neuropathic Pain Scale [ Time Frame: 6 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- EQ-5D [ Time Frame: 6 months ]
- Numeric Rating Scale for pain [ Time Frame: 6 months ]
Original Secondary Outcome: Same as current
Information By: William Beaumont Hospitals
Dates:
Date Received: May 2, 2008
Date Started: April 2008
Date Completion:
Last Updated: January 23, 2017
Last Verified: September 2012
