Clinical Trial: Investigating the Role of EN in NTIS Among Fistula Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: a Prospective Study to Investigate the Role of Enteral Nutrition in Nonthyroidal Illness Syndrome Among Fistula Patients

Brief Summary: The purpose of this study is to investigate whether enteral nutrition are effective in the treatment of nonthyroidal illness syndrome among fistula patients.

Detailed Summary: Nonthyroidal illness syndrome (NTIS) is a common alterations in thyroid function observed in about 70% of hospitalized patients, with or without acute systemic illnesses. Mechanisms in the pathogenesis of NTIS are not yet well understood. Our previous study demonstrated that NTIS occurred frequently with a prevalence of 57.5% in gastrointestinal fistulas patients. In recent study, it has been shown that early enteral nutrition decreases the duration of hospitalization and mortality in the burn population, indicating a potential role of enteral nutrition in NTIS.In addition, the management of fistula patients requires bundle therapy including Nutrition therapy, especially enteral nutrition.The purpose of this study is to investigate whether enteral nutrition are effective in the treatment of nonthyroidal illness syndrome among fistula patients.
Sponsor: Jinling Hospital, China

Current Primary Outcome: Thyroid function [ Time Frame: Changes of thyroid function from baseline at 1 week,2 week, 3 week and 4 week after enrolled. ]

Thyroid function assessment includes level of free triiodothyronine,total triiodothyronine,free thyroxin,total thyroxin,thyroid stimulating hormone,thyroid stimulating hormone index,and standard thyroid stimulating hormone index


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Jinling Hospital, China

Dates:
Date Received: January 10, 2014
Date Started: January 2013
Date Completion:
Last Updated: June 27, 2014
Last Verified: June 2014