Clinical Trial: Topical Application of Latanoprost in Diabetic Retinopathy

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Topical Application of Latanoprost in Diabetic Retinopathy

Brief Summary: Randomized double-blinded two-year intervention study with topical application of latanoprost or placebo eye drops in patients with diabetic retinopathy.

Detailed Summary:

The primary objective is to study if a sustained contraction of pathologically dilated retinal arterioles can be obtained. Retinal arteriolar diameter and the diameter response to increased blood pressure is studied using the Dynamic Vessel Analyzer (Imedos, Germany.

The secondary objective is to study whether the intervention can halt the development of diabetic retinopathy, which is assessed by optical coherence tomography (OCT) scanning and fundus photography.


Sponsor: University of Aarhus

Current Primary Outcome: The diameter of retinal arterioles [ Time Frame: 24 months ]

The diameter of retinal arterioles will be assessed using the Dynamic Vessel Analyzer


Original Primary Outcome: The diameter of retinal arterioles [ Time Frame: After 24 months ]

The diameter of retinal arterioles will be assessed using the Dynamic Vessel Analyzer


Current Secondary Outcome: The severity of diabetic retinopathy [ Time Frame: 24 months ]

Severity of diabetic retinopathy will be measured by optical coherence tomography (OCT) scanning and fundus photography


Original Secondary Outcome: The severity of diabetic retinopathy [ Time Frame: After 24 months ]

Severity of diabetic retinopathy will be measured by optical coherence tomography (OCT) scanning and fundus photography


Information By: University of Aarhus

Dates:
Date Received: October 20, 2010
Date Started: November 2010
Date Completion:
Last Updated: December 17, 2014
Last Verified: December 2014