Clinical Trial: Contribution Of Nuclear Magnetic Resonance Imaging In The Study Of Diabetic Cardiomyopathy

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Contribution Of Nuclear Magnetic Resonance Imaging In The Study Of Diabetic Cardiomyopathy

Brief Summary: Diagnosis of diabetic cardiomyopathy is then retained, supposing a change in the coronary microcirculation linked to an endothelial dysfunction. Abnormalities of the myocardial metabolism is frequently associated. It is regrettably about a hypothesis difficult to verify with current medical techniques.This deficiency being not only harmful to the diagnosis, but also to the assessment of the efficiency of the medical treatment on the myocardial metabolism and the endothelial function. Techniques of nuclear magnetic resonance offer interesting perspectives.

Detailed Summary:

These techniques allow in this context:

  1. to quantify the myocardial blood flow at rest and after "cold pressor test" in a population of healthy volunteers. The myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique.

  2. to estimate the metabolic and structural abnormalities in this population, with particularly:

    • Quantification of the myocardial metabolism in vivo by spectrometry of phosphorus 31.
    • Structural abnormalities: become integrated into the description of diabetic cardiomyopathy.

Sponsor: Assistance Publique Hopitaux De Marseille

Current Primary Outcome: To quantify the myocardial blood flow at rest and after "cold pressor test" in a population of healthy volunteers [ Time Frame: 12 months ]

The myocardial blood flow will be obtained by estimating myocardial blood flow at the venous coronary sinus site. This allows us to quantify a possible endothelial dysfunction in a reproducible way. No MRI study in diabetic patients has ever been led until now with this technique.


Original Primary Outcome: Same as current

Current Secondary Outcome: To estimate the metabolic and structural abnormalities in this population [ Time Frame: 12 months ]

  • Quantification of the myocardial metabolism in vivo by spectrometry of phosphorus 31 which allows to estimate the energy state of the heart by analyzing the phosphorous metabolites with high energy involved in the myocardial energetic metabolism.
  • Structural abnormalities: evaluation of the fibrosis and the collagenic deposits by T1 mapping and measurement of relaxation T2 as well as the study of the late enhancement of gadolinium. These structural abnormalities become integrated into the description of diabetic cardiomyopathy.


Original Secondary Outcome: Same as current

Information By: Assistance Publique Hopitaux De Marseille

Dates:
Date Received: January 26, 2011
Date Started: February 2011
Date Completion: June 2015
Last Updated: April 20, 2015
Last Verified: April 2015