Clinical Trial: Mechanisms Responsible for Cardiac and Skeletal Muscle Energetic Impairment in Diabetes

Study Status: Not yet recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Mechanisms Responsible for Cardiac and Skeletal Muscle Energetic Impairment in Diabetes

Brief Summary: Diabetes increases the risk of heart failure. This is mainly due to a disease of the blood vessels supplying the heart muscle and/or high blood pressure, but abnormal metabolism may also contribute. We plan to study the mechanisms involved in this abnormal metabolism, whilst also assessing the effects of a drug called Perhexiline which improves the abnormal metabolism that is present in diabetic patients before the development of heart failure.

Detailed Summary:
Sponsor: University Hospital Birmingham

Current Primary Outcome: The primary end point of the Perhexiline intervention study will be the change in cardiac PCr/ATP ratio. [ Time Frame: 2 Weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital Birmingham

Dates:
Date Received: February 24, 2008
Date Started: October 2006
Date Completion: April 2009
Last Updated: February 24, 2008
Last Verified: February 2008