Clinical Trial: Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Non Invasive Monitoring of Cerebral Blood Flow During and After Cardiopulmonary Bypass to Assess and Compare for the Presence of Delirium in Post Operative Patients (

Brief Summary: Cardiac surgery is associated with multiple events and issues that increase risk for adverse postoperative neurological outcomes including postoperative cognitive dysfunction. The risk for postoperative delirium is generally thought to result from some previous health factors added to the susceptibility of the cardiac surgery process.

Detailed Summary:

Cardiac surgery is associated with multiple perturbations that increase risk for adverse postoperative neurological outcomes including postoperative cognitive dysfunction. These same perturbations likely also increase the risk for postoperative delirium although there are little data that have evaluated this hypothesis.

As the subject is prepared for surgery 2 contact probes will be placed on the forehead to monitor the rSO2 and cerebral blood flow. This monitor can also measureblood flow velocity in blood vessels in the forehead.

This will only be done while the subject is on the cardiac bypass machine during the surgery and end shortly after entering the intensive care unit.Prior to surgery and then once a day on three of the first four postoperative days, patients will be assessed for the presence and severity of delirium with brief standard psychological exams. We will compare rSO2 and CBF changes between patients with and without delirium


Sponsor: Johns Hopkins University

Current Primary Outcome: To evaluate whether rSO2 and/or CBF during CPB is lower in patients who experience delirium within three days after cardiac surgery compared with patients without delirium [ Time Frame: 3 days post op ]

To evaluate whether rSO2 and/or CBF during CPB is lower in patients who experience delirium within three days after cardiac surgery compared with patients without delirium.


Original Primary Outcome: Same as current

Current Secondary Outcome: recovery pattern of rSO2 [ Time Frame: 3 post op days ]

To evaluate the recovery pattern of rSO2 and CBF for up to 6 hrs after CPB for ICU patients who experience delirium within three days after cardiac surgery compared with patients without delirium.


Original Secondary Outcome: Same as current

Information By: Johns Hopkins University

Dates:
Date Received: February 25, 2014
Date Started: June 2013
Date Completion:
Last Updated: February 5, 2016
Last Verified: February 2016