Clinical Trial: Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A Double-Blind, Randomized, Placebo-Controlled Study of Perioperative Administration of Olanzapine to Prevent Postoperative Delirium in Joint Replacement Patients

Brief Summary: In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.

Detailed Summary: Postoperative delirium is a serious and common (20% to 60%) complication in orthopedic surgery patients. In this study we investigate whether prophylactic administration of olanzapine can prevent delirium from occurring after knee or hip replacement in high-risk patients > 65 years of age. This is a randomized, double-blind, single center, placebo-controlled study.
Sponsor: The New England Baptist Hospital

Current Primary Outcome: incidence of delirium [ Time Frame: days in hospital ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Complications, length of stay, hospital costs [ Time Frame: days ]

Original Secondary Outcome: Same as current

Information By: The New England Baptist Hospital

Dates:
Date Received: June 16, 2008
Date Started: January 2005
Date Completion:
Last Updated: January 19, 2009
Last Verified: January 2009