Clinical Trial: Role of T Helper 17 and Regulatory T Cells in Delayed Graft Function

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Can T Helper 17 and Regulatory T Cells Explain the Pathophysiology of Delayed Graft Function in Renal Transplant Recipients?

Brief Summary: Delayed graft function (DGF) increases risk of acute rejection after kidney transplantation (KTx). Interleukin-6, which is produced in DGF, is critical in directing naive T helper cells differentiation towards T helper 17 (Th17) and away from regulatory T (Treg) cells. The investigators hypothesize there is an increase in Th17 and a decrease in Treg expression in KTx recipients with DGF compared to those without, leading to immunologic consequences. The investigators will test their hypothesis by measuring in both groups expression of Th17, Treg, and related cytokines in blood, urine, kidney biopsy, and kidney preservation fluid, and correlating these results with immunologic events.

Detailed Summary: All adult recipients of a primary kidney transplant will be eligible. Subjects will have blood samples drawn from which we will isolate lymphocytes and analyze the Treg population based on surface markers as well as a functional assay. The measures of Treg function will be compared to outcomes including DGF, graft survival and graft function, as well as the development of immunological complications such as donor-specific antibody production, acute rejection, IFTA and opportunistic infection.
Sponsor: McGill University Health Center

Current Primary Outcome: Graft function [ Time Frame: 1 year ]

Kidney graft function as measured by GFR


Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: McGill University Health Center

Dates:
Date Received: October 30, 2010
Date Started: July 2010
Date Completion: December 2019
Last Updated: September 12, 2016
Last Verified: September 2016