Clinical Trial: Residual Neuromuscular Blockade in Pediatric Anesthesia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Residual Neuromuscular Blockade in Paediatric Patients Before Extubation and in Postanesthetic Care Unit:Prospective Observational Cohort Study

Brief Summary: Residual neuromuscular blockade (RNB) is frequent and it is associated with postoperative morbidity and mortality. The incidence of the RNB in pediatric anesthesia is currently not known. The aim of this prospective observational cohort study is to evaluate the early RNB just before extubation and late RNB at the time of arrival to postanesthetic care unit (PACU).

Detailed Summary: Residual neuromuscular blockade (RNB) is frequent and it is associated with negative impact on postoperative morbidity and mortality. The incidence of the RNB in adult is well described, however in pediatric subpopulation it is currently not known. The aim of this prospective observational cohort study is to evaluate the early RNB just before extubation and late RNB at the time of arrival to postanesthetic care unit (PACU). In the trial will be enrolled all pediatric patients (28 weeks of age and older - 19 years old) whom will be administered neuromuscular blocking agent during anesthesia. The demographic data will be collected including: age, weight, type of surgery, ASA status. The anesthesia management will be described including: airway management, type and cumulative dose of neuromuscular blocking agent (NMBA) and time and dose of the last administered bolus of NMBA. The residual neuromuscular blockade will be measured according to the standards: TOF Watch accelerometry at the moment prior to extubation (two measurements) in TOF mode and at the arrival to postanesthetic care unit (PACU) (two measurements) in TOF mode.
Sponsor: Brno University Hospital

Current Primary Outcome: Early residual neuromuscular blockade [ Time Frame: before extubation ]

Just prior extubation the residual neuromuscular blockade will be measured by accelerometry


Original Primary Outcome: Early residual neuromuscular blockade [ Time Frame: 6 months ]

Just prior extubation the residual neuromuscular blockade will be measured by accelerometry


Current Secondary Outcome: Late neuromuscular blockade [ Time Frame: at arrival to PACU ]

At the arrival to PACU the residual neuromuscular blockade will be measured by accelerometry


Original Secondary Outcome: Late neuromuscular blockade [ Time Frame: 6 months ]

At the arrival to PACU the residual neuromuscular blockade will be measured by accelerometry


Information By: Brno University Hospital

Dates:
Date Received: October 18, 2016
Date Started: January 2017
Date Completion: December 2017
Last Updated: January 13, 2017
Last Verified: January 2017