Clinical Trial: Automated Control of End-tidal Volatile Anesthetic Concentration

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Automated Control of End-tidal Volatile Anesthetic Concentration Using the MIRUS System: A Comparison of Isoflurane, Sevoflurane and Desflurane in Anesthesia.

Brief Summary: The new MIRUS system as well as the established AnaConDa system uses a reflector to conserve volatile anaesthetics (VA). Both systems act with commercially available ICU ventilators. In contrast to AnaConDa the MIRUS includes an automated control of end-tidal VA concentrations. In this study the investigators compared feasibility, costs and recovery times after anaesthesia with isoflurane (ISO), sevoflurane (SEVO) or desflurane (DES) in ventilated and spontaneously breathing patients.

Detailed Summary: The study was approved by the appropriate Institutional Review Board. After written informed consent 63 ASA I-III patients undergoing elective hip or knee replacement surgery under general anesthesia were included. Patients were randomly organized into 3 groups (20-22 each). Anesthesia was induced with intravenous anaesthetics. After tracheal intubation MIRUS automatically adjusted the end-tidal VA concentration to 1.0 MAC. Patients were ventilated with the Puritan Bennett 840 ICU ventilator. After 1 h of anaesthesia with 1.0 MAC the ventilator mode was switched from SIMV V+ (totally controlled ventilation, "passive patient", with a tidal volume of 8 ml/IBW) to proportional assist ventilation (PAV) with 50% support ("active patient"). At the end of surgery the MIRUS system was stopped (MAC set to 0.0) and recovery times were measured.
Sponsor: Ruhr University of Bochum

Current Primary Outcome: volatile anaesthetics (VA) consumption [ Time Frame: duration of anesthesia: max. 3 h ]

Original Primary Outcome: Same as current

Current Secondary Outcome: recovery times [ Time Frame: duration post anesthesia care: max. 8 h after anesthesia ]

Original Secondary Outcome: Same as current

Information By: Ruhr University of Bochum

Dates:
Date Received: January 6, 2015
Date Started: September 2014
Date Completion:
Last Updated: January 14, 2015
Last Verified: January 2015