Clinical Trial: Evaluation of PET CT in the Management of Patients With Crohn's Disease.

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Evaluation of PET CT in the Management of Patients With Crohn's Disease.

Brief Summary: 18F-FDG PET/CT (2-[fluorine-18] fluoro-2-deoxy-D-glucose, Positron emission tomography- CT) is a noninvasive technique that allows quantifying and precisely localizing 18F-FDG uptake in the entire body. 18F-FDG uptake is caused by increased local metabolic activity. Such increased uptake has been described not only in neoplastic lesions but also in inflammatory lesions. In this condition, uptake has been correlated with local stimulation of tumor necrosis factor, and with monocyte priming and activation. A physiologic variable uptake may be observed in the bowel, especially the cecum, and has limited the use of PET in inflammatory bowel diseases. The advantage of combined PET and CT devices lead to significant improvements in the interpretation of the bowel areas, and greatly reduces the number of false-positive findings in the gastrointestinal tract.

Detailed Summary:
Sponsor: Rabin Medical Center

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Rabin Medical Center

Dates:
Date Received: August 3, 2008
Date Started: April 2008
Date Completion: October 2010
Last Updated: December 22, 2008
Last Verified: February 2008