Clinical Trial: Weight Gain in Surgically Treated Adult-onset Craniopharyngioma

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Weight Gain in Surgically Treated Adult-onset Craniopharyngioma

Brief Summary: The aim of the study was to describe postoperative weight change in adults undergoing surgery for craniopharyngioma and identify preoperative factors associated with it.

Detailed Summary: Morbid obesity, intractable weight gain due to hypothalamic damage, is a common and troubling complication in patients undergoing surgery for craniopharyngioma combined or not with radiotherapy, with an incidence of 23~62% in pediatric patients. It has a major negative impact on metabolic and cardiovascular health and quality of life in long-term survivors. Identifying patients at higher risks for developing postoperative weight gain is of great importance in preventing obesity and taking early actions in this population. Though a lot of previous studies have been made in pediatric patients and several factors, such as hypothalamic involvement, higher body mass index (BMI) standard deviation score (SDS) at diagnosis, age at diagnosis and hydrocephalus requiring a shunt, have been identified as risk factors for postoperative weight gain, data on this important morbidity in adult-onset patients are sparse, especially in Chinese population. Therefore, the investigators are going to undertake a retrospective evaluation of postoperative weight change in adult-onset patients undergoing surgery for craniopharyngioma and identify preoperative factors associated with it.
Sponsor: Huashan Hospital

Current Primary Outcome: percentage of postoperative weight gain [ Time Frame: 2.5 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Huashan Hospital

Dates:
Date Received: October 20, 2013
Date Started: July 2013
Date Completion:
Last Updated: October 20, 2013
Last Verified: October 2013