Clinical Trial: Cranial Nerves Tractography

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Diffusion Tensor Imaging and Tractography for Cranial Nerves. Interest in Skull Base Surgery and Anatomy

Brief Summary:

Introduction: The skull base tumors surgery remains a challenge since numerous cranial nerves or vessels closely surround them. Recently, diffusion tensor imaging has developed with the tractography following white fibers and visualizing functional tracts. Cranial nerves tractography could allow predicting their displacement by skull base tumors that may help the surgeon to spare them along the surgery.

Methods: Preoperative cerebral MRI was performed on patients who presented with skull base tumors. A 3 tesla MRI machine was used to acquire DTI sequence with specific parameters: 32 directions, slice thickness 2 mm, echo time 86 ms, repetition time 12000 ms, matrix 128x128, b-value 1000 s.mm-1. An anatomic sequence hyperT2 was overlaid as reference. Distortion was corrected by topup and eddy functions from FSL. Cranial nerves fibers were probabilistically tracked with Mrtrix3. Cranial nerves were selected according to their location around the tumor. The "radiological" expected position of the cranial nerve was compared to its "operative" real position.


Detailed Summary:
Sponsor: Hospices Civils de Lyon

Current Primary Outcome:

  • Correlation between the expected and the real position of the selected cranial nerve [ Time Frame: Date of preoperative MRI (<3 months before the surgery) ]
    Selection of one or multiples cranial nerves of interest due to their close relationship with the tumor. Comparison of its/their position on MRI and during surgery.
  • Correlation between the expected and the real position of the selected cranial nerve [ Time Frame: at 3 months ]
    Selection of one or multiples cranial nerves of interest due to their close relationship with the tumor. Comparison of its/their position on MRI and during surgery.


Original Primary Outcome: Same as current

Current Secondary Outcome: postoperative cranial nerve palsy [ Time Frame: at 3 months ]

comparison with preoperative status


Original Secondary Outcome: Same as current

Information By: Hospices Civils de Lyon

Dates:
Date Received: November 23, 2016
Date Started: July 2016
Date Completion: July 2018
Last Updated: November 29, 2016
Last Verified: November 2016