Clinical Trial: Bronchial Hyper-responsiveness in Reflux Cough
Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional
Official Title: An 8 Week Non-selected Cohort Study to Investigate Whether the Treatment of Reflux Induced Cough Alters Associated Bronchial Hyper-responsiveness
Brief Summary: The study aim is to determine the effect of 8 weeks of anti-reflux treatment (full acid suppression) on bronchial hyper-responsiveness and whether there is a symptomatic improvement.
Detailed Summary:
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Current Primary Outcome: Change in Methacholine Sensitivity [ Time Frame: baseline and 8 weeks ]
Concentration of methacholine (mg/ml) at which participants forced expired volume in 1 sec (FEV1) is reduced by 20% (the provocation concentration of methacholine causing a 20% fall in FEV1-PC20).
To measure if there is a significant difference in PC20 recorded at baseline to that recorded following 8 weeks treatment with omeprazole and ranitidine
Original Primary Outcome: Reduction in methacholine sensitivity [ Time Frame: 8 weeks ]
Current Secondary Outcome: Improvement in Cough Symptoms Measured Using Leicester Cough Questionnaire [ Time Frame: 8 weeks ]
Original Secondary Outcome: nprovement in cough symptoms measured using Leicester cough questionnaire [ Time Frame: 8 weeks ]
Information By: Hull and East Yorkshire Hospitals NHS Trust
Dates:
Date Received: April 24, 2008
Date Started: September 2006
Date Completion:
Last Updated: October 16, 2012
Last Verified: October 2012
