Clinical Trial: Lidocaine: Effect of Lidocaine in Chronic Cough

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Lidocaine and Its Delivery in Patients With Chronic Cough

Brief Summary:

People cough in order to clear their airways. Most coughs are caused by viruses and settle down by themselves, but some people develop persistent coughing which can be anywhere from 8 weeks to several years. This is called chronic cough. People with chronic cough find the symptom distressing and it can have a major impact on their quality of life. Patients with chronic cough often report a sensation at the back of their throat which makes them feel an urge to cough. There is some evidence that Lidocaine (an anaesthetic used during medical procedures) can suppress a person's cough when given to patients via a nebuliser (a machine that turns liquid into a fine mist).

It is currently unknown whether using a local anaesthetic, such as Lidocaine, in the form of a throat spray would successfully suppress a person's cough. A throat spray would be an easier treatment option in chronic cough patients. Thus, the investigators research aims to compare cough rates, severity and urge to cough scores between Lidocaine throat spray and nebulised Lidocaine.


Detailed Summary:
Sponsor: University Hospital of South Manchester NHS Foundation Trust

Current Primary Outcome: Objective cough counts over 10 hours post dose. Change in Urge to cough and Visual Analogue Score (VAS). [ Time Frame: over 24 hours following treatment ]

patients will wear a cough recorder device for a 24 hour period. The recordings will then be analysed to reveal how many times the patient coughed.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Heart rate [ Time Frame: over 2 hours ]
    to document any change in heart rate after treatment
  • Mouth Numbness [ Time Frame: over 24 hours following treatment ]
    Duration of mouth numbness will be subjectively assessed by asking patients about the presence of mouth numbness and its duration after treatment.
  • Electrocardiogram (ECG) [ Time Frame: 15 minutes after treatment ]
    ECG will be recorded before treatment and 15 minutes after treatment to rule out any arrhythmias


Original Secondary Outcome: Same as current

Information By: University Hospital of South Manchester NHS Foundation Trust

Dates:
Date Received: November 29, 2010
Date Started: February 2011
Date Completion:
Last Updated: September 15, 2011
Last Verified: September 2011