Clinical Trial: Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults

Brief Summary: Cough is a defensive behavior that involves three stages. A large inspiratory phase, a compression phase where the vocal folds close and subglottal pressure is developed, and an expiratory phase. Cough serves to protect the upper and lower airways from material such as liquids, solids, or saliva, that have been aspirated. There are two types of cough: voluntary and reflex cough. Voluntary cough involves a cough to command. Reflex cough is a cough that is generated secondary to a stimulus in or near the airway. There has been some research regarding the differences between voluntary and reflex cough. However, no research has described the differences in airflow or movement pattern (kinematics) between the two types of cough. This study seeks to determine the respiratory kinematics and airflow differences between voluntary and reflex cough in healthy participants.

Detailed Summary:

As a participant, completion of this study will require the following:

Investigators will first place cotton elastic bands around your chest and abdomen so that measures of chest wall and abdominal movements can be measured. Then, tests of your breathing made from pulmonary function testing will be completed.

Investigators will then have you complete a maximum inspiration followed by a maximum expiration three times.

Investigators will ask you to produce a voluntary cough three times into a facemask which is attached to a computer.

Then the investigators will provide you with nebulized water (FOG) through the facemask for up to a minute three times. You will have a minute break in between each presentation.

Finally, the investigators will provide you with a nebulized dose of Capsaicin, which is derived from hot peppers, through the same facemask used in all of the above tasks. You will receive three doses of capsaicin and be provided with water at any time during the study.


Sponsor: University of Florida

Current Primary Outcome: Lung Volume Initiation [ Time Frame: 1 hour ]

Respiratory kinematic measure: lung volume initiation (LVI) Lung volume initiation is a measure of the volume of air in the lungs prior to a respiratory task.


Original Primary Outcome: Respiratory kinematics during voluntary and reflex cough in healthy adults [ Time Frame: 1 hour ]

Respiratory kinematic measures: lung volume initiation (LVI), lung volume termination (LVT), and total lung volume excursion (LVE).

Airflow measures: Compression phase duration, peak expiratory flow rate, peak expiratory flow rise time, and cough volume acceleration.



Current Secondary Outcome:

  • Peak Expiratory Airflow Rate [ Time Frame: 1 hour ]
    Airflow measures: Peak expiratory airflow rate Peak expiratory flow rate is a measure of the velocity of air expelled from the respiratory apparatus during cough. Measured in liters/second.
  • Urge-to-cough [ Time Frame: 1 hour ]
    Urge-to-cough: A measure of respiratory sensation that rates the perceived magnitude of the need to cough on a Borg scale (0=no urge-to-cough; 10=maximal urge-to-cough).


Original Secondary Outcome: Respiratory kinematics during voluntary and reflex cough in healthy adults [ Time Frame: 1 hour ]

Urge to cough rating: Borg scale (0-10; 0 equals no urge to cough, 10 equals maximal urge to cough)


Information By: University of Florida

Dates:
Date Received: May 10, 2013
Date Started: May 2013
Date Completion:
Last Updated: September 15, 2015
Last Verified: September 2015