Clinical Trial: 4 Repeat Tauopathy Neuroimaging Initiative

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Observational Longitudinal Study of Magnetic Resonance Imaging, Specimen Biomarkers, and Clinical Progression in Progressive Supranuclear Palsy and Corticobasal Degeneration

Brief Summary: The purpose of this study is to evaluate several different tests, including brain imaging, eye movement testing, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence in the hope that this information can be used to guide diagnosis and treatment of PSP and CBD in the future. Recent advances in our understanding of the biological causes of these diseases offer hope for new treatments. As such treatments are developed, sensitive and specific biological measurements (biomarkers) will be needed to provide precise and direct measures of the state of the brain, which will improve the statistical power of clinical trials. Brain imaging with Magnetic Resonance Imaging (MRI) has previously been used to measure disease-related changes in the brain. The goal of this study is to identify the best methods of analysis (including eye movements, imaging, and behavioral measures) for tracking PSP and CBD over time. In addition, certain biomarkers in the blood and cerebrospinal fluid might also be useful for following these diseases over time. This study will examine the value of blood and CSF biomarkers relative to brain imaging and functional measures.

Detailed Summary:
Sponsor: University of California, San Francisco

Current Primary Outcome: Progressive Supranuclear Palsy Rating Scale [ Time Frame: Baseline, 6 months and 1 year ]

Change from baseline


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Eye movement function [ Time Frame: Baseline, 6 months and 1 year ]
    Change from baseline
  • Brain volume on MRI [ Time Frame: Baseline, 6 months and 1 year ]
    Change from baseline.


Original Secondary Outcome: Same as current

Information By: University of California, San Francisco

Dates:
Date Received: January 18, 2013
Date Started: January 2011
Date Completion: December 2017
Last Updated: May 5, 2017
Last Verified: May 2017