Clinical Trial: A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respiratory Syndrome

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: A Multi-centre, Double-blinded, Randomized, Placebo-controlled Trial on the Efficacy and Safety of Lopinavir / Ritonavir Plus Ribavirin in the Treatment of Severe Acute Respirato

Brief Summary: The study aims to examine whether the combination of Lopinavir/Ritonavir plus Ribavirin for treatment of severe acute respiratory syndrome (SARS) is superior to placebo.

Detailed Summary:
Sponsor: Hospital Authority, Hong Kong

Current Primary Outcome: Development of severe SARS [ Time Frame: Any time during the acute illness ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Adverse events [ Time Frame: Throughout the illness period ]
  • SARS-CoV Viral load [ Time Frame: Throughout the illness period ]
  • Immunological profile [ Time Frame: Throughout the illness period ]


Original Secondary Outcome: Same as current

Information By: Hospital Authority, Hong Kong

Dates:
Date Received: December 20, 2007
Date Started:
Date Completion:
Last Updated: August 21, 2013
Last Verified: August 2013