Clinical Trial: Abnormal Coronary Vasomotion in Patients With Suspected Coronary Artery Disease (CAD)

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries

Brief Summary: In patients with chest pain and/or shortness of breath coronary artery disease (CAD) is suspected depending on the pattern of symptoms and the electrocardiogram (ECG). Coronary angiography is the method of choice to verify this suspicion. If the patient coronary arteries on coronary angiography are totally normal, one can only speculate if the patients' discomfort is from the heart or not. A possibility to get further information about the healthiness of the coronary arteries is the acetylcholine test (ACH-test). When injecting this natural, body produced-substance into the coronary arteries one can test if the vessels coronary spasm which can be the reason for the patient's symptoms. The investigators therefore use this test in this study to look for coronary spasm in patients with suspected CAD but normal coronary arteries. In case of a positive test, the patient profits from having found a cause for his/her symptoms making treatment with special tablets possible. Furthermore, the investigators want to analyze blood samples of every patient to look for signs of inflammation that seem to be linked with coronary spasms. On the basis of these results the ACH-test could probably be avoided in the future.

Detailed Summary:
Sponsor: Peter Ong, MD

Current Primary Outcome: all cause mortality (cardiac vs. non-cardiac) [ Time Frame: 12-36 months ]

Original Primary Outcome: all cause mortality [ Time Frame: 6 months ]

Current Secondary Outcome: Angina pectoris, repeated angiography, re-admissions for angina pectoris [ Time Frame: 12-36 months ]

Original Secondary Outcome: Angina pectoris [ Time Frame: 6 months ]

Information By: Robert Bosch Medical Center

Dates:
Date Received: June 8, 2009
Date Started: November 2007
Date Completion: December 2019
Last Updated: April 26, 2017
Last Verified: April 2017