Clinical Trial: Endothelial Dysfunction and Coronary Artery Spasm

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Digital Tonometry for Measurement of Peripheral Artery Reactive Hyperemia as Non-invasive Test for Diagnosis of Coronary Artery Spasm

Brief Summary: Non-obstructive coronary artery disease (NOCAD) frequently accounts for myocardial ischemia in women. Endothelial dysfunction is a pathogenic factor in coronary spastic angina (CSA). CSA is an important cause of NOCAD diagnosed invasively by coronary angiography (CAG). Digital reactive hyperemia peripheral arterial tonometry (RH-PAT) provides noninvasive evaluation of endothelial dysfunction. The investigators hypothesized that the fingertip RH-PAT could predict the presence of CSA in women.

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RH-PAT was measured in women with chest pain prior to CAG. Coronary spasm was diagnosed by intra-coronary acetylcholine (ACh) provocation test. Using Flow-Wire, we assessed coronary endothelial function by coronary blood flow increase in response to ACh (ACh-CBF) and coronary flow reserve was assessed by adenosine (Ad-CFR).

Sponsor: Kumamoto University

Current Primary Outcome: Ischemic heart disease diagnosed by cardiac catheterization [ Time Frame: From Aug 2006 to May 2009 ]

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Information By: Kumamoto University

Dates:
Date Received: February 8, 2008
Date Started: August 2006
Date Completion:
Last Updated: September 25, 2013
Last Verified: September 2013