Clinical Trial: Detection of Coronary Stenosis With Intravenous Microbubbles

Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Interventional

Official Title: The Detection of Coronary Stenosis With Intravenous Mircrobubbles and Contrast Pulse Sequence Low Mechanical Index Imaging

Brief Summary: To detect coronary artery disease by both coronary and carotid artery imaging and myocardial perfusion imaging using a new low mechanical index real time system.

Detailed Summary: The objective of this clinical study will be to visualize both coronary and carotid arteries as well as detect myocardial perfusion following a routine intravenous injection of Definity (0.05-0.20 millimeters), Optison (0.1-0.4 millimeters) or PESDA (0.05-0.2 mL). Following these injections , we will attempt to Contrast Pulse Sequencing on the Siemens Acuson Sequoia system to image both the coronary and carotid arteries, as well as the Myocardial perfusion.
Sponsor: University of Nebraska

Current Primary Outcome: To determine whether this imaging scheme can detect both coronary and carotid artery stenoses as well as perfusion defects during a standard echocardiographic examination [ Time Frame: 2-4 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Visually analyze the coronary and carotid arteries as well as perfusion defects during a standard echocardiogram examination [ Time Frame: immediate ]

Original Secondary Outcome: Same as current

Information By: University of Nebraska

Dates:
Date Received: December 18, 2007
Date Started: February 2012
Date Completion: March 2014
Last Updated: July 19, 2012
Last Verified: July 2012