Clinical Trial: Determinants of Changes in Arterial Load Following Exercise
Study Status: RECRUITING
Recruit Status: RECRUITING
Study Type: INTERVENTIONAL
Official Title: Determinants of Changes in Arterial Load Following Exercise
Brief Summary: The goal of this study is to learn about how blood vessel dilation after exercise effects pulse wave reflection and influences the function of the heart in healthy young adults.
The main question it aims to answer is: Are post-exercise decreases in reflected pulse waves due to a decrease in the stiffness of large arteries in the leg or an increase in leg blood flow?
Participants will exercise on a stationary bicycle at a moderate intensity for 1 hour during two laboratory visits.
Participants will take oral antihistamines to block post-exercise dilation at one visit, and they will take placebo pills at the other visit.
At both visits, leg blood flow, pulse wave velocity, and heart function will be measured before exercise and for 120-minutes after exercise.
Detailed Summary:
During exercise, blood vessels increase in size to supply muscles with more blood.
After exercise, the muscles that had been used release chemicals called histamines that cause the blood vessels to stay dilated even when the muscles no longer need more blood.
It takes around 2 hours for the blood vessels to return to normal.
This causes blood pressure to be lower than it usually is at rest.
This phenomenon delays the return of pressure waves in arteries that are reflected back to the heart resulting in the heart having to work less hard to pump out blood for about 2 hours after exercise.
However, it is unknown why the reflected pressure waves return to the heart later.
The aim of this study is to determine if this delay is due to the speed of the reflected waves being slowed by large arteries or dilation of small arteries resulting in the reflections originating further from the heart.
By giving antihistamines prior to exercise, post-exercise blood vessel dilation of the small arteries will be largely reduced, thus allowing for the determination of which factor causes the reflected waves to return later.
Additionally, it is hypothesized that the reduction in work that the heart must perform results in improved contraction and relaxation of the heart.
Thus, an additional aim is to determine how post-exercise blood vessel dilation influence heart function.
To accomplish these aims, blood flow leaving the left ventricle and femoral blood flow will be measured via Doppler ultrasound.
Applanation tonometry will be used to record pulse waves at the carotid, radial, femoral, and dorsalis pedis arteries.
These pulse waves will be used to estimate central blood pressure and to determine pulse wave velocity of different arterial segments.
Measurements will be made at baseline and for 120 minutes after a bout of moderate intensity aerobic exercise.
Sponsor: University of Delaware
Current Primary Outcome: Arterial stiffness of the leg will be assessed via measurement of femoral-pedis pulse wave velocity.
Original Primary Outcome: Arterial stiffness of the leg will be assessed via measurement of femoral-pedis pulse wave velocity.
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University of Delaware
Dates:
Date Received: March 16, 2023
Date Started: May 12, 2023
Date Completion: May 12, 2023
Last Updated: November 27, 2023
Last Verified: November 01, 2023
