Clinical Trial: Psychotherapy and Pharmacotherapy in Dissociative Disorders

Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational

Official Title: The Interest of a Specific Combined Treatment (Psychotherapy and Pharmacotherapy) in Patients With Dissociative Disorders

Brief Summary: The purpose of this observational study is to measure the efficacy of a specific combined treatment (psychotherapy and pharmacotherapy) on patients with dissociative disorders, in terms of patients with a favorable outcome by means of the Dissociative Experiences Scale (DES).

Detailed Summary:

  1. INTRODUCTION

    1. Background: Dissociative Disorders are frequent, but poorly understood and under-diagnosed [Foote et al., 2006; Spiegel, 2006], especially in psychiatric emergency units [Lazignac et al., 2005]. The management of this is commonly mixed up with psychotic, depressive and anxiety disorders.

      The treatment of the dissociative disorders remains controversial. The psychotherapeutic guidelines proposed by International Society for the Study of Dissociative Disorders (ISSD) were recently adapted for the French speaking users [Damsa et al., 2005]. There is no consensus on which antipsychotic or antidepressant would be preferable for those patients who suffer from dissociative disorders, accompanied by depressive or psychotic symptoms. We have a very good clinical experience with quetiapine and escitalopram for this specific group of patients.

    2. Rationale for this study; Clinical [Lazignac et al., 2005] and neurobiological [Kelley-Puskas et al., 2005] reviews on dissociative disorders emphasize the value of a first open label study on the effects of specific combined psychotherapy and pharmacotherapy in patients with dissociative disorders [Damsa et al., 2006].

  2. STUDY OBJECTIVES

    1. Primary objective

      • The efficacy of specific combined psychotherapy and pharmacotherapy in patients with dissociative disorders, in terms of favorable outco
        Sponsor: Espace Hogan

        Current Primary Outcome: To study the efficacy of a specific combined treatment (psychotherapy and pharmacotherapy) on patients with dissociative disorders, in terms of patients with a favorable outcome by means of the DES scale. [ Time Frame: 8 weeks ]

        Original Primary Outcome: Same as current

        Current Secondary Outcome: The relationship between serum lipid levels and depressive symptoms in patients with dissociative disorder during combined treatment. [ Time Frame: 8 weeks ]

        Original Secondary Outcome: - the relationship between serum lipid levels and depressive symptoms in patients with dissociative disorder during combined treatment. [ Time Frame: 8 weeks ]

        Information By: Espace Hogan

        Dates:
        Date Received: February 28, 2008
        Date Started: February 2008
        Date Completion: July 2009
        Last Updated: April 16, 2009
        Last Verified: April 2009