Clinical Trial: Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC "

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification : MOMIC

Brief Summary: Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.

Detailed Summary:
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Current Primary Outcome: - To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM [ Time Frame: 08/2011 ]

Original Primary Outcome: Same as current

Current Secondary Outcome: - To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis [ Time Frame: 08/2011 ]

Original Secondary Outcome: Same as current

Information By: Institut National de la Santé Et de la Recherche Médicale, France

Dates:
Date Received: February 4, 2010
Date Started: February 2010
Date Completion:
Last Updated: February 23, 2016
Last Verified: February 2016