Clinical Trial: Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism
Brief Summary: This is a clinical study comparing targeted levothyroxine dosing based on thyroid anatomy as visualized on ultrasound (normal vs. ectopic/sublingual vs. athyreosis) to empiric levothyroxine dosing in infants with congenital hypothyroidism. Patients enrolled in the study for targeted dosing will be compared to controls obtained by retrospective chart review. The main outcome is to determine if there is a difference in the frequency of over-treatment and under-treatment during the first 6 months of therapy.
Detailed Summary:
Sponsor: Erica Eugster
Current Primary Outcome: Thyroid hormones test (thyroid-stimulating hormone (TSH and fT4/T4) [ Time Frame: 6 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Time to euthyroidism following diagnosis [ Time Frame: 6 months ]
Original Secondary Outcome: Same as current
Information By: Indiana University
Dates:
Date Received: February 18, 2015
Date Started: March 2014
Date Completion:
Last Updated: March 21, 2017
Last Verified: March 2017