Clinical Trial: Molecular Typing of Community-acquired Pneumonia Based on Multiple-omic Data Analysis
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Molecular Typing of Adult Community-acquired Pneumonia in China
Brief Summary:
Community-acquired pneumonia (CAP) is a heterogeneous disease causing great morbidity, mortality and health care burden globally. Typing methods for discriminating different clinical conditions of the same disease are essential to a better management of CAP. Traditional typing systems based separately on clinical manifestations (such as PSI and CURB-65), pathogens(bacterial types, virulence, drug resistance, etc) or host immune state (immunocompetent, immunocompromised or immunodeficiency). Thus, they are barely able to represent the real disease status nor to precisely predict the mortality.
As the development of multi-omic technologies, the relatedness of different phenotypes at a molecular level have revolutionized our ability to differentiate among patients. Our study is aimed at establishing a novel molecular typing method of CAP. Multi-omic (including genomics, transcriptomes, and metabolisms) data obtained from enrolled CAP patients and isolated pathogens would be integrated analyzed and interpreted. Tthe investigators believe that an appropriate molecular typing method would lead to revolutionary changes in current arrangements of CAP.
Detailed Summary:
Sponsor: Peking University People's Hospital
Current Primary Outcome: 30 day mortality [ Time Frame: 30 days after the onset of CAP ]
Original Primary Outcome: Same as current
Current Secondary Outcome: complications [ Time Frame: 30 days after the onset of CAP ]
Original Secondary Outcome: Same as current
Information By: Peking University People's Hospital
Dates:
Date Received: March 15, 2017
Date Started: March 2017
Date Completion: December 2018
Last Updated: March 22, 2017
Last Verified: March 2017
