Clinical Trial: the Impact of Paediatric Use of Proton Pump Inhibitors on the Risk of Community Acquired Infections.

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: A Cohort Study to Assess the Impact of Paediatric Use of Proton Pump Inhibitors on the Risk of Community Acquired Infections

Brief Summary:

Pharmacological treatment of physiologic Gastro-esophageal Reflux disease (GERD) is excessive in France, as 65%-85% of children below 11 years are being treated, frequently with Proton Pump Inhibitors (PPIs) PPI have been associated, in adults, with an increase of infection rate but data in pediatry are scarce, especially in community medecine. Recently a study conducted in England brought up controversial results suggesting that the use of PPIs can be associated with a reduced risk of community acquired pneumonia.

Our study was aimed to assess, on a population-based database, the association between PPI prescription and community infections in children of 11 years or under.


Detailed Summary:
Sponsor: Centre Hospitalier Universitaire Dijon

Current Primary Outcome: Number of overall infections [ Time Frame: 4 years ]

Comparison of number of infections between PPI exposed and non-exposed children. All infections are taken in account


Original Primary Outcome: Same as current

Current Secondary Outcome: Number of specific infections [ Time Frame: 4 years ]

Comparison of number of infections between PPI exposed and non-exposed


Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Universitaire Dijon

Dates:
Date Received: April 26, 2017
Date Started: March 2015
Date Completion:
Last Updated: April 28, 2017
Last Verified: April 2017