Clinical Trial: CHROENDOHNPCC: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Early Detection of Pre-cancer Lesions in Adults With Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Syndrome: Assessment of Coloscopy With Chromoscopy Benefit

Brief Summary: The aim of the study is to test the hypothesis that a chromoscopy colonoscopy is able to increase by 50 % the number of pre-cancer lesions or early cancer detected in patients with HNPCC syndrome, compared to a routine colonoscopy without chromoscopy.

Detailed Summary: Patient with HNPCC syndrome confirmed by a mutation (MLH1, MSH2, MHS1) are involved in the study. Patient have 2 colonoscopy back to back. The second coloscopy is associated to chromoscopy with carmin indigo. Endoscopist are randomised for the colonoscopy with chromoscopy and are un-awarded of the result of the first colonoscopy. Histopathology of the polyp are noted. The follow up were 1 month.
Sponsor: Assistance Publique - Hôpitaux de Paris

Current Primary Outcome: Number of pre-cancer lesions or early cancer detected. [ Time Frame: during the procedure ]

Original Primary Outcome: Number of pre-cancer lesions or early cancer detected.

Current Secondary Outcome: Anatomopathologic criteria (size of lesions, …). [ Time Frame: during the procedure ]

Original Secondary Outcome: Anatomo-pathologic criteria (size of lesions, …).

Information By: Assistance Publique - Hôpitaux de Paris

Dates:
Date Received: September 16, 2005
Date Started: July 2005
Date Completion:
Last Updated: February 17, 2011
Last Verified: July 2007