Clinical Trial: The Effect of Yohimbine on Cocaine Cue Reactivity
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: SCOR on Sex and Gender Factors Affecting Women's Health
Brief Summary: Stress and cues reminiscent of cocaine use promote craving and relapse in cocaine dependent individuals. In addition, there appears to be gender differences in determinants of relapse to drug use following abstinence in cocaine-dependent individuals. Therefore the purpose of the present study is to study the role of hormonal status on the response to cocaine-related cues with or without stress in cocaine-dependent women and men.
Detailed Summary: Cocaine dependence is an insidious disease underscored by a strong propensity to relapse despite knowledge of the repercussions of continued drug-use. Stress and cocaine cues produce craving and ultimately relapse in cocaine dependent individuals. Pre-clinical research has demonstrated sex differences in response to cocaine-conditioned cues and cocaine-primed reinstatement, which correlates well with reduced plasma progesterone levels. Interestingly, this is consistent with a growing body of clinical literature indicating that progesterone may decrease the reinforcing properties of stimulants in women. Gender differences in the response to a social stressor and cocaine cues in cocaine-dependent individuals have been demonstrated in human laboratory studies, however, the interaction of stress and cues and the effect of hormonal status on response have not been explored. This study examines the role of hormonal status on the response to cocaine-related cues with or without a pharmacological stressor (yohimbine) in cocaine-dependent women and men. As a further integration of the research focus this study also explores the relationship between impulsivity and craving.
Sponsor: Medical University of South Carolina
Current Primary Outcome: Cocaine craving [ Time Frame: Post cocaine cue exposure ]
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Medical University of South Carolina
Dates:
Date Received: September 21, 2007
Date Started: September 2007
Date Completion:
Last Updated: March 27, 2013
Last Verified: March 2013
