Clinical Trial: Buprenorphine Naltrexone-P1 A-Cocaine

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Attenuation of Opioid Effects of Three Different Doses of Sublingual Buprenorphine / Naloxone by Oral Naltrexone in Healthy Volunteers

Brief Summary: The purpose of this study is to determine if the opioid agonist effects of doses of 4/1 mg, 8/2 mg, and 16/4 mg of buprenorphine/naloxone can be completely blocked by 50 mg of oral naltrexone. This study will provide data to support the design of a similar study of the depot formulation of naltrexone and ultimately to study this combination for the treatment of cocaine dependence.

Detailed Summary:
Sponsor: National Institute on Drug Abuse (NIDA)

Current Primary Outcome: Opioid Effects of study drug [ Time Frame: daily ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Adverse Events [ Time Frame: Daily ]

Original Secondary Outcome: Same as current

Information By: National Institute on Drug Abuse (NIDA)

Dates:
Date Received: August 11, 2008
Date Started: August 2008
Date Completion:
Last Updated: January 11, 2017
Last Verified: October 2009