Clinical Trial: Cluster Headache, Addictions and Vascular Function

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational [Patient Registry]

Official Title: Cluster Headache (CH), Addictions and Vascular Function

Brief Summary: Cluster headache (CH) is one of the most painful primitive headaches. Developments in neuroimaging have demonstrated activation of the ipsilateral hypothalamic and orexinergic system, which is similar in patients with addictions. CH has strong links to the vascular system but there is no study measuring endothelial function in CH sufferers.

Detailed Summary:

Several studies have shown an association between Cluster headache (CH) and smoking. However, no data exists on the link between CH and other addictions, and impact of these addictions on clinical characteristics of the disease. In addition, despite the strong biological link between CH and the vascular system, systematic investigations about vascular functions in CH patients are lacking.

This will be a prospective cohort study of 150 patients with CH, conducted in the Headache Center in Bordeaux, France.


Sponsor: University Hospital, Bordeaux

Current Primary Outcome:

  • Duration of active periods of cluster headache [ Time Frame: Day 0 (Inclusion visit) ]
  • Number of active periods [ Time Frame: Day 0 (Inclusion visit) ]
  • Duration of cluster headache [ Time Frame: Day 0 (Inclusion visit) ]
  • Severity of attacks [ Time Frame: Day 0 (Inclusion visit) ]
  • Duration of active periods of cluster headache [ Time Frame: one year after inclusion ]
  • Number of active periods [ Time Frame: one year after inclusion ]
  • Duration of cluster headache [ Time Frame: one year after inclusion ]
  • Severity of attacks [ Time Frame: one year after inclusion ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Existence of an addiction [ Time Frame: Day 0 (Inclusion visit) ]
  • Existence of an addiction [ Time Frame: One year after inclusion ]
  • Severity of Addiction [ Time Frame: Day 0 (Inclusion visit) ]
  • Severity of Addiction [ Time Frame: One year after inclusion ]
  • Reactive Hyperemic Index (RHI) [ Time Frame: Day 0 (Inclusion visit) ]
    Endothelial function measurement


Original Secondary Outcome: Same as current

Information By: University Hospital, Bordeaux

Dates:
Date Received: November 23, 2015
Date Started: June 2014
Date Completion: June 2017
Last Updated: December 21, 2015
Last Verified: December 2015